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Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres
The activation of a telomere maintenance mechanism is required for cancer development in humans. While most tumors achieve this by expressing the enzyme telomerase, a fraction (5–15%) employs a recombination-based mechanism termed alternative lengthening of telomeres (ALT). Here we show that loss of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2175364/ https://ncbi.nlm.nih.gov/pubmed/17959650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm738 |
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