Aminoglycoside binding to the HIV-1 RNA dimerization initiation site: thermodynamics and effect on the kissing-loop to duplex conversion

Owing to a striking, and most likely fortuitous, structural and sequence similarity with the bacterial 16 S ribosomal A site, the RNA kissing-loop complex formed by the HIV-1 genomic RNA dimerization initiation site (DIS) specifically binds 4,5-disubstituted 2-deoxystreptamine (2-DOS) aminoglycoside...

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Detalhes bibliográficos
Main Authors: Bernacchi, Serena, Freisz, Séverine, Maechling, Clarisse, Spiess, Bernard, Marquet, Roland, Dumas, Philippe, Ennifar, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175338/
https://ncbi.nlm.nih.gov/pubmed/17942426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm856
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