Modeling DNA-binding of Escherichia coli σ(70) exhibits a characteristic energy landscape around strong promoters

We present a computational model of DNA-binding by σ(70) in Escherichia coli which allows us to extract the functional characteristics of the wider promoter environment. Our model is based on a measure for the binding energy of σ(70) to the DNA, which is derived from promoter strength data and used...

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Huvudupphovsmän: Weindl, Johanna, Hanus, Pavol, Dawy, Zaher, Zech, Juergen, Hagenauer, Joachim, Mueller, Jakob C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2007
Ämnen:
Computational Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175306/
https://ncbi.nlm.nih.gov/pubmed/17940097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm720
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