Local conservation scores without a priori assumptions on neutral substitution rates

BACKGROUND: Comparative genomics aims to detect signals of evolutionary conservation as an indicator of functional constraint. Surprisingly, results of the ENCODE project revealed that about half of the experimentally verified functional elements found in non-coding DNA were classified as unconstrai...

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Main Authors: Dingel, Janis, Hanus, Pavol, Leonardi, Niccolò, Hagenauer, Joachim, Zech, Jürgen, Mueller, Jakob C
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375903/
https://ncbi.nlm.nih.gov/pubmed/18405366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-9-190
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