The C2b Domain of Synaptotagmin Is a Ca(2+)–Sensing Module Essential for Exocytosis

The synaptic vesicle protein synaptotagmin I has been proposed to serve as a Ca(2+) sensor for rapid exocytosis. Synaptotagmin spans the vesicle membrane once and possesses a large cytoplasmic domain that contains two C2 domains, C2A and C2B. Multiple Ca(2+) ions bind to the membrane proximal C2A do...

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Main Authors: Desai, Radhika C., Vyas, Bimal, Earles, Cynthia A., Littleton, J. Troy, Kowalchyck, Judith A., Martin, Thomas F.J., Chapman, E.R.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2000
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175261/
https://ncbi.nlm.nih.gov/pubmed/10974000
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