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Liberation of Doxorubicin from HPMA Copolymer Conjugate is Essential for the Induction of Cell Cycle Arrest and Nuclear Fragmentation in Ovarian Carcinoma Cells

Despite intensive study, the molecular mechanism for cell toxicity of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound doxorubicin remains unclear. Moreover, the ability of the released drug to accumulate in the nucleus has also been questioned. We have hypothesized that the pattern of cell...

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Detalhes bibliográficos
Main Authors: Malugin, A., Kopečková, P., Kopeček, J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175206/
https://ncbi.nlm.nih.gov/pubmed/17869367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2007.08.016
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