Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity

Excessive release of glutamate and the subsequent influx of calcium are associated with a number of neurological insults that result in neuronal death. The calcium-activated intracellular signaling pathways responsible for this excitotoxic injury are largely unknown. Here, we report that PD098059, a...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Murray, Beverley, Alessandrini, Alessandro, Cole, Andrew J., Yee, Ann G., Furshpan, Edwin J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21750/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751775/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11975
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