Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions

Caspase-11, a member of the murine caspase family, has been shown to be an upstream activator of caspase-1 in regulating cytokine maturation. We demonstrate here that in addition to its defect in cytokine maturation, caspase-11–deficient mice have a reduced number of apoptotic cells and a defect in...

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Hlavní autoři: Kang, Shin-Jung, Wang, Suyue, Hara, Hideaki, Peterson, Erin P., Namura, Shobu, Amin-Hanjani, Sepideh, Huang, Zhihong, Srinivasan, Anu, Tomaselli, Kevin J., Thornberry, Nancy A., Moskowitz, Michael A., Yuan, Junying
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2000
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174843/
https://ncbi.nlm.nih.gov/pubmed/10791975
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