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Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes

Cell-based antitumor immunity is driven by CD8(+) cytotoxic T cells bearing TCR that recognize specific tumor-associated peptides bound to class I MHC molecules. Of several cellular proteins involved in T cell:target-cell interaction, the TCR determines specificity of binding; however, the relative...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Johnson, Laura A., Heemskerk, Bianca, Powell, Daniel J., Cohen, Cyrille J., Morgan, Richard A., Dudley, Mark E., Robbins, Paul F., Rosenberg, Steven A.
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	2006
الموضوعات:	Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2174608/ https://ncbi.nlm.nih.gov/pubmed/17056587
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes

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