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Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions

Coculture of melanoma cells and T cell clones derived from tumor- infiltrating lymphocytes (TIL) generally results in lysis of the antigen-bearing tumor cells but to inefficient proliferation and IL-2 secretion by responder T cells. This suboptimal activation is classically explained by an inability...

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Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1996
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192543/
https://ncbi.nlm.nih.gov/pubmed/8642353
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