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Caspases Disrupt the Nuclear-Cytoplasmic Barrier

During apoptosis, caspases, a family of proteases, disassemble a cell by cleaving a set of proteins. Caspase-3 plays a major role in the disassembly of the nucleus by processing several nuclear substrates. The question is how caspase-3, which is usually cytoplasmic, gains access to its nuclear targe...

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Bibliographic Details
Main Authors: Faleiro, Lavina, Lazebnik, Yuri
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2000
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174353/
https://ncbi.nlm.nih.gov/pubmed/11085998
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