Hypoxia-inducible Factor-1α Stabilization in Nonhypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion

Hypoxia-inducible factor-1 (HIF-1) is a decisive element for the transcriptional regulation of many genes induced under low oxygen conditions. Under normal oxygen conditions, HIF-1α, the active subunit of HIF-1, is hydroxylated on proline residues by specific HIF prolyl-hydroxylases, leading to ubiq...

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Autores principales: Pagé, Elisabeth L., Chan, Denise A., Giaccia, Amato J., Levine, Mark, Richard, Darren E.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2008
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174200/
https://ncbi.nlm.nih.gov/pubmed/17942596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-06-0612
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