Ca(2+)-dependent Calmodulin Binding to FcRn Affects Immunoglobulin G Transport in the Transcytotic Pathway

The Fcγ receptor FcRn transports immunoglobulin G (IgG) so as to avoid lysosomal degradation and to carry it bidirectionally across epithelial barriers to affect mucosal immunity. Here, we identify a calmodulin-binding site within the FcRn cytoplasmic tail that affects FcRn trafficking. Calmodulin b...

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Autori principali: Dickinson, Bonny L., Claypool, Steven M., D'Angelo, June A., Aiken, Martha L., Venu, Nanda, Yen, Elizabeth H., Wagner, Jessica S., Borawski, Jason A., Pierce, Amy T., Hershberg, Robert, Blumberg, Richard S., Lencer, Wayne I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174181/
https://ncbi.nlm.nih.gov/pubmed/18003977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-07-0658
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