PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure

The type 1 ryanodine receptor (RyR1) on the sarcoplasmic reticulum (SR) is the major calcium (Ca(2+)) release channel required for skeletal muscle excitation–contraction (EC) coupling. RyR1 function is modulated by proteins that bind to its large cytoplasmic scaffold domain, including the FK506 bind...

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Detalhes bibliográficos
Main Authors: Reiken, Steven, Lacampagne, Alain, Zhou, Hua, Kherani, Aftab, Lehnart, Stephan E., Ward, Chris, Huang, Fannie, Gaburjakova, Marta, Gaburjakova, Jana, Rosemblit, Nora, Warren, Michelle S., He, Kun-lun, Yi, Geng-hua, Wang, Jie, Burkhoff, Daniel, Vassort, Guy, Marks, Andrew R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173774/
https://ncbi.nlm.nih.gov/pubmed/12629052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200211012
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