Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β(2)-adrenergic receptor

cAMP controls many cellular processes mainly through the activation of protein kinase A (PKA). However, more recently PKA-independent pathways have been established through the exchange protein directly activated by cAMP (Epac), a guanine nucleotide exchange factor for the small GTPases Rap1 and Rap...

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Main Authors: Rangarajan, Savithri, Enserink, Jorrit M., Kuiperij, H. Bea, de Rooij, Johan, Price, Leo S., Schwede, Frank, Bos, Johannes L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173739/
https://ncbi.nlm.nih.gov/pubmed/12578910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200209105
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