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Isoform-specific insulin receptor signaling involves different plasma membrane domains
In pancreatic β-cells, insulin selectively up-regulates the transcription of its own gene and that of the glucokinase gene by signaling through the two isoforms of the insulin receptor, i.e., A-type (Ex11−) and B-type (Ex11+), using different signaling pathways. However, the molecular mechanism(s) t...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173728/ https://ncbi.nlm.nih.gov/pubmed/14691140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200306093 |
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