Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease

The rat homologue of a mitochondrial ATP-dependent protease Lon was cloned from cultured astrocytes exposed to hypoxia. Expression of Lon was enhanced in vitro by hypoxia or ER stress, and in vivo by brain ischemia. These observations suggested that changes in nuclear gene expression (Lon) triggered...

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Detalhes bibliográficos
Main Authors: Hori, Osamu, Ichinoda, Fusae, Tamatani, Takashi, Yamaguchi, Atsushi, Sato, Naoya, Ozawa, Kentaro, Kitao, Yasuko, Miyazaki, Mayuki, Harding, Heather P., Ron, David, Tohyama, Masaya, M Stern, David, Ogawa, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173558/
https://ncbi.nlm.nih.gov/pubmed/12082077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200108103
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