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AP-1 binding to sorting signals and release from clathrin-coated vesicles is regulated by phosphorylation

The adaptor protein complex-1 (AP-1) sorts and packages membrane proteins into clathrin-coated vesicles (CCVs) at the TGN and endosomes. Here we show that this process is highly regulated by phosphorylation of AP-1 subunits. Cell fractionation studies revealed that membrane-associated AP-1 differs f...

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Bibliografski detalji
Glavni autori: Ghosh, Pradipta, Kornfeld, Stuart
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173368/
https://ncbi.nlm.nih.gov/pubmed/12604586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200211080
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