Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling

In platelets, the nitric oxide (NO)–induced cGMP response is indicative of a highly regulated interplay of cGMP formation and cGMP degradation. Recently, we showed that within the NO-induced cGMP response in human platelets, activation and phosphorylation of phosphodiesterase type 5 (PDE5) occurred....

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Bibliographic Details
Main Authors: Mullershausen, Florian, Friebe, Andreas, Feil, Robert, Thompson, W. Joseph, Hofmann, Franz, Koesling, Doris
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173359/
https://ncbi.nlm.nih.gov/pubmed/12604588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200211041
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