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Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins
The binding of urokinase plaminogen activator (uPA) to its cell surface receptor (uPAR; CD87) promotes cell adhesion by increasing the affinity of the receptor for both vitronectin (VN) and integrins. We provide evidence that plasminogen activator inhibitor (PAI)-1 can detach cells by disrupting uPA...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2003
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173358/ https://ncbi.nlm.nih.gov/pubmed/12615913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200208117 |
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