Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1.

XR5118 [(3 Z,6 Z )-6-benzylidine-3-(5-(2-dimethylaminoethyl-thio-))-2-(thienyl)methylene-2,5-dipiperazinedione hydrochloride] can inactivate the anti-proteolytic activity of the serpin plasminogen activator inhibitor-1 (PAI-1), a potential therapeutic target in cancer and cardiovascular diseases. Se...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Einholm, Anja P, Pedersen, Katrine E, Wind, Troels, Kulig, Paulina, Overgaard, Michael T, Jensen, Jan K, Bødker, Julie S, Christensen, Anni, Charlton, Peter, Andreasen, Peter A
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223537/
https://ncbi.nlm.nih.gov/pubmed/12723974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021880
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados