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Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins

The binding of urokinase plaminogen activator (uPA) to its cell surface receptor (uPAR; CD87) promotes cell adhesion by increasing the affinity of the receptor for both vitronectin (VN) and integrins. We provide evidence that plasminogen activator inhibitor (PAI)-1 can detach cells by disrupting uPA...

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Bibliografiske detaljer
Main Authors: Czekay, Ralf-Peter, Aertgeerts, Kathleen, Curriden, Scott A., Loskutoff, David J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173358/
https://ncbi.nlm.nih.gov/pubmed/12615913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200208117
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