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The importin-β binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro
The nuclear localization signal (NLS) of spliceosomal U snRNPs is composed of the U snRNA's 2,2,7-trimethyl-guanosine (m(3)G)-cap and the Sm core domain. The m(3)G-cap is specifically bound by snurportin1, which contains an NH(2)-terminal importin-β binding (IBB) domain and a COOH-terminal m(3)...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173342/ https://ncbi.nlm.nih.gov/pubmed/11815630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200108114 |
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