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The importin-β binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro

The nuclear localization signal (NLS) of spliceosomal U snRNPs is composed of the U snRNA's 2,2,7-trimethyl-guanosine (m(3)G)-cap and the Sm core domain. The m(3)G-cap is specifically bound by snurportin1, which contains an NH(2)-terminal importin-β binding (IBB) domain and a COOH-terminal m(3)...

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Autori principali: Huber, Jochen, Dickmanns, Achim, Lührmann, Reinhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173342/
https://ncbi.nlm.nih.gov/pubmed/11815630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200108114
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