Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

EGF, but not TGFα, efficiently induces degradation of the EGF receptor (EGFR). We show that EGFR was initially polyubiquitinated to the same extent upon incubation with EGF and TGFα, whereas the ubiquitination was more sustained by incubation with EGF than with TGFα. Consistently, the ubiquitin liga...

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Hauptverfasser: Longva, Karianne E., Blystad, Frøydis D., Stang, Espen, Larsen, Astrid M., Johannessen, Lene E., Madshus, Inger H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173306/
https://ncbi.nlm.nih.gov/pubmed/11864992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200106056
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