Defective Rac-mediated proliferation and survival after targeted mutation of the β(1) integrin cytodomain

Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of β(1) integrin leads to defective proliferation and survival both in vivo and in vitro. Primary murine embryonic fibroblasts (MEFs) derived from mutant homoz...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hirsch, Emilio, Barberis, Laura, Brancaccio, Mara, Azzolino, Ornella, Xu, Dazhong, Kyriakis, John M., Silengo, Lorenzo, Giancotti, Filippo G., Tarone, Guido, Fässler, Reinhard, Altruda, Fiorella
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2002
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173276/
https://ncbi.nlm.nih.gov/pubmed/11980921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200111065
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