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Defective Rac-mediated proliferation and survival after targeted mutation of the β(1) integrin cytodomain
Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of β(1) integrin leads to defective proliferation and survival both in vivo and in vitro. Primary murine embryonic fibroblasts (MEFs) derived from mutant homoz...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173276/ https://ncbi.nlm.nih.gov/pubmed/11980921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200111065 |
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