Defective Rac-mediated proliferation and survival after targeted mutation of the β(1) integrin cytodomain

Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of β(1) integrin leads to defective proliferation and survival both in vivo and in vitro. Primary murine embryonic fibroblasts (MEFs) derived from mutant homoz...

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Detaylı Bibliyografya
Asıl Yazarlar: Hirsch, Emilio, Barberis, Laura, Brancaccio, Mara, Azzolino, Ornella, Xu, Dazhong, Kyriakis, John M., Silengo, Lorenzo, Giancotti, Filippo G., Tarone, Guido, Fässler, Reinhard, Altruda, Fiorella
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2002
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173276/
https://ncbi.nlm.nih.gov/pubmed/11980921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200111065
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