Defective Rac-mediated proliferation and survival after targeted mutation of the β(1) integrin cytodomain

Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of β(1) integrin leads to defective proliferation and survival both in vivo and in vitro. Primary murine embryonic fibroblasts (MEFs) derived from mutant homoz...

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Detalhes bibliográficos
Main Authors: Hirsch, Emilio, Barberis, Laura, Brancaccio, Mara, Azzolino, Ornella, Xu, Dazhong, Kyriakis, John M., Silengo, Lorenzo, Giancotti, Filippo G., Tarone, Guido, Fässler, Reinhard, Altruda, Fiorella
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173276/
https://ncbi.nlm.nih.gov/pubmed/11980921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200111065
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