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Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER
BACE457 is a recently identified pancreatic isoform of human β-secretase. We report that this membrane glycoprotein and its soluble variant are characterized by inefficient folding in the ER, leading to proteasome-mediated ER-associated degradation (ERAD). Dissection of the degradation process revea...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173128/ https://ncbi.nlm.nih.gov/pubmed/12119363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200204122 |
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