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β-site specific intrabodies to decrease and prevent generation of Alzheimer's Aβ peptide
Endoproteolysis of the β-amyloid precursor protein (APP) by β- and γ-secretases generates the toxic amyloid β-peptide (Aβ), which accumulates in the brain of Alzheimer's disease (AD) patients. Here, we established a novel approach to regulate production of Aβ based on intracellular expression o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171775/ https://ncbi.nlm.nih.gov/pubmed/15767460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200410047 |
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