Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration

RhoA activity is transiently inhibited at the initial phase of integrin engagement, when Cdc42- and/or Rac1-mediated membrane spreading and ruffling predominantly occur. Paxillin, an integrin-assembly protein, has four major tyrosine phosphorylation sites, and the phosphorylation of Tyr31 and Tyr118...

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Autores principales: Tsubouchi, Asako, Sakakura, Junko, Yagi, Ryohei, Mazaki, Yuichi, Schaefer, Erik, Yano, Hajime, Sabe, Hisataka
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173105/
https://ncbi.nlm.nih.gov/pubmed/12446743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200202117
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