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Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration
RhoA activity is transiently inhibited at the initial phase of integrin engagement, when Cdc42- and/or Rac1-mediated membrane spreading and ruffling predominantly occur. Paxillin, an integrin-assembly protein, has four major tyrosine phosphorylation sites, and the phosphorylation of Tyr31 and Tyr118...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173105/ https://ncbi.nlm.nih.gov/pubmed/12446743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200202117 |
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