BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac

The phenotype of hematopoietic cells transformed by the BCR/ABL oncoprotein of the Philadelphia chromosome is characterized by growth factor-independent proliferation, reduced susceptibility to apoptosis, and altered adhesion and motility. The mechanisms underlying this phenotype are not fully under...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Skorski, Tomasz, Wlodarski, Pawel, Daheron, Laurence, Salomoni, Paolo, Nieborowska-Skorska, Malgorzata, Majewski, Miroslaw, Wasik, Mariusz, Calabretta, Bruno
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21730/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751755/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11858
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