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BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac

The phenotype of hematopoietic cells transformed by the BCR/ABL oncoprotein of the Philadelphia chromosome is characterized by growth factor-independent proliferation, reduced susceptibility to apoptosis, and altered adhesion and motility. The mechanisms underlying this phenotype are not fully under...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Skorski, Tomasz, Wlodarski, Pawel, Daheron, Laurence, Salomoni, Paolo, Nieborowska-Skorska, Malgorzata, Majewski, Miroslaw, Wasik, Mariusz, Calabretta, Bruno
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21730/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751755/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11858
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