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A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation

Activating mutations in FGF receptor 3 (FGFR3) cause several human dwarfism syndromes by affecting both chondrocyte proliferation and differentiation. Using microarray and biochemical analyses of FGF-treated rat chondrosarcoma chondrocytes, we show that FGF inhibits chondrocyte proliferation by init...

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Detalhes bibliográficos
Main Authors: Dailey, Lisa, Laplantine, Emmanuel, Priore, Riccardo, Basilico, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172997/
https://ncbi.nlm.nih.gov/pubmed/12821644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200302075
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