Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A

To test the hypothesis that fast anterograde molecular motor proteins power the slow axonal transport of neurofilaments (NFs), we used homologous recombination to generate mice lacking the neuronal-specific conventional kinesin heavy chain, KIF5A. Because null KIF5A mutants die immediately after bir...

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Autores principales: Xia, Chun-Hong, Roberts, Elizabeth A., Her, Lu-Shiun, Liu, Xinran, Williams, David S., Cleveland, Don W., Goldstein, Lawrence S.B.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2003
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172877/
https://ncbi.nlm.nih.gov/pubmed/12682084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200301026
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