Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A

To test the hypothesis that fast anterograde molecular motor proteins power the slow axonal transport of neurofilaments (NFs), we used homologous recombination to generate mice lacking the neuronal-specific conventional kinesin heavy chain, KIF5A. Because null KIF5A mutants die immediately after bir...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Xia, Chun-Hong, Roberts, Elizabeth A., Her, Lu-Shiun, Liu, Xinran, Williams, David S., Cleveland, Don W., Goldstein, Lawrence S.B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2003
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172877/
https://ncbi.nlm.nih.gov/pubmed/12682084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200301026
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