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Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A
To test the hypothesis that fast anterograde molecular motor proteins power the slow axonal transport of neurofilaments (NFs), we used homologous recombination to generate mice lacking the neuronal-specific conventional kinesin heavy chain, KIF5A. Because null KIF5A mutants die immediately after bir...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172877/ https://ncbi.nlm.nih.gov/pubmed/12682084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200301026 |
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