Loading...

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

Alzheimer's amyloid precursor protein 695 (APP) is a plasma membrane protein, which is known to be the source of the toxic amyloid β (Aβ) peptide associated with the pathogenesis of Alzheimer's disease (AD). Here we demonstrate that by virtue of its chimeric NH(2)-terminal signal, APP is a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Anandatheerthavarada, Hindupur K., Biswas, Gopa, Robin, Marie-Anne, Avadhani, Narayan G.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172865/
https://ncbi.nlm.nih.gov/pubmed/12695498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200207030
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!