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Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P(3) and polarity during neutrophil chemotaxis
Neutrophils exposed to chemoattractants polarize and accumulate polymerized actin at the leading edge. In neutrophil-like HL-60 cells, this asymmetry depends on a positive feedback loop in which accumulation of a membrane lipid, phosphatidylinositol (PI) 3,4,5-trisphosphate (PI[3,4,5]P(3)), leads to...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2003
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172671/ https://ncbi.nlm.nih.gov/pubmed/12551955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200208179 |
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