Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P(3) and polarity during neutrophil chemotaxis

Neutrophils exposed to chemoattractants polarize and accumulate polymerized actin at the leading edge. In neutrophil-like HL-60 cells, this asymmetry depends on a positive feedback loop in which accumulation of a membrane lipid, phosphatidylinositol (PI) 3,4,5-trisphosphate (PI[3,4,5]P(3)), leads to...

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Main Authors: Srinivasan, Supriya, Wang, Fei, Glavas, Suzana, Ott, Alexander, Hofmann, Fred, Aktories, Klaus, Kalman, Daniel, Bourne, Henry R.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172671/
https://ncbi.nlm.nih.gov/pubmed/12551955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200208179
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