A foldable CFTRΔF508 biogenic intermediate accumulates upon inhibition of the Hsc70–CHIP E3 ubiquitin ligase

CFTRΔF508 exhibits a correctable protein-folding defect that leads to its misfolding and premature degradation, which is the cause of cystic fibrosis (CF). Herein we report on the characterization of the CFTRΔF508 biogenic intermediate that is selected for proteasomal degradation and identification...

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Main Authors: Younger, J. Michael, Ren, Hong-Yu, Chen, Liling, Fan, Chun-Yang, Fields, Andrea, Patterson, Cam, Cyr, Douglas M.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2004
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172621/
https://ncbi.nlm.nih.gov/pubmed/15611333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200410065
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