A foldable CFTRΔF508 biogenic intermediate accumulates upon inhibition of the Hsc70–CHIP E3 ubiquitin ligase

CFTRΔF508 exhibits a correctable protein-folding defect that leads to its misfolding and premature degradation, which is the cause of cystic fibrosis (CF). Herein we report on the characterization of the CFTRΔF508 biogenic intermediate that is selected for proteasomal degradation and identification...

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Hlavní autoři: Younger, J. Michael, Ren, Hong-Yu, Chen, Liling, Fan, Chun-Yang, Fields, Andrea, Patterson, Cam, Cyr, Douglas M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2004
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172621/
https://ncbi.nlm.nih.gov/pubmed/15611333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200410065
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