Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis

Despite the potential of the inhibitor of apoptosis proteins (IAPs) to block cytochrome c–dependent caspase activation, the critical function of IAPs in regulating mammalian apoptosis remains unclear. We report that the ability of endogenous IAPs to effectively regulate caspase activation depends on...

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Bibliographic Details
Main Authors: Wright, Kevin M., Linhoff, Michael W., Potts, Patrick Ryan, Deshmukh, Mohanish
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2004
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172554/
https://ncbi.nlm.nih.gov/pubmed/15504912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200406073
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