Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP

Overexpression studies have identified X-linked inhibitor of apoptosis protein (XIAP) as a potent inhibitor of caspases. However, the exact function of endogenous XIAP in regulating mammalian apoptosis is less clear. Endogenous XIAP strictly regulates cytochrome c–dependent caspase activation in sym...

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Main Authors: Potts, Malia B., Vaughn, Allyson E., McDonough, Holly, Patterson, Cam, Deshmukh, Mohanish
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2005
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171313/
https://ncbi.nlm.nih.gov/pubmed/16344307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200504082
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