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Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

We have found that key mitotic regulators show distinct patterns of degradation during exit from mitosis in human cells. Using a live-cell assay for proteolysis, we show that two of these regulators, polo-like kinase 1 (Plk1) and Aurora A, are degraded at different times after the anaphase-promoting...

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Sonraí Bibleagrafaíochta
Main Authors: Lindon, Catherine, Pines, Jonathon
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2004
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172335/
https://ncbi.nlm.nih.gov/pubmed/14734534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200309035
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