BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci

The molecular mechanism involved in the process of antigen-driven somatic hypermutation of Ig genes is unknown, but it is commonly believed that this mechanism is restricted to the Ig loci. B cell lymphomas commonly display multiple somatic mutations clustering in the 5′-regulatory region of BCL-6,...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Pasqualucci, Laura, Migliazza, Anna, Fracchiolla, Nicola, William, Christopher, Neri, Antonino, Baldini, Luca, Chaganti, R. S. K., Klein, Ulf, Küppers, Ralf, Rajewsky, Klaus, Dalla-Favera, Riccardo
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1998
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21723/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11816
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