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Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin
Ezrin, a membrane–actin cytoskeleton linker, which participates in epithelial cell morphogenesis, is held inactive in the cytoplasm through an intramolecular interaction. Phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding and the phosphorylation of threonine 567 (T567) are involved in the activa...
Tallennettuna:
| Päätekijät: | , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The Rockefeller University Press
2004
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172172/ https://ncbi.nlm.nih.gov/pubmed/14993232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200307032 |
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