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Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

Ezrin, a membrane–actin cytoskeleton linker, which participates in epithelial cell morphogenesis, is held inactive in the cytoplasm through an intramolecular interaction. Phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding and the phosphorylation of threonine 567 (T567) are involved in the activa...

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Detalhes bibliográficos
Main Authors: Fievet, Bruno T., Gautreau, Alexis, Roy, Christian, Del Maestro, Laurence, Mangeat, Paul, Louvard, Daniel, Arpin, Monique
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172172/
https://ncbi.nlm.nih.gov/pubmed/14993232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200307032
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