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The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation
Before S phase, cells license replication origins for initiation by loading them with Mcm2-7 heterohexamers. This process is dependent on Cdc6, which is recruited to unlicensed origins. Using Xenopus egg extracts we show that although each origin can load many Mcm2-7 hexamers, the affinity of Cdc6 f...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2004
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172031/ https://ncbi.nlm.nih.gov/pubmed/15096526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200311044 |
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