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Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects

Because JunB is an essential gene for placentation, it was conditionally deleted in the embryo proper. JunB (Δ/Δ) mice are born viable, but develop severe low turnover osteopenia caused by apparent cell-autonomous osteoblast and osteoclast defects before a chronic myeloid leukemia-like disease. Alth...

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Autors principals: Kenner, Lukas, Hoebertz, Astrid, Beil, Timo, Keon, Niamh, Karreth, Florian, Eferl, Robert, Scheuch, Harald, Szremska, Agnieszka, Amling, Michael, Schorpp-Kistner, Marina, Angel, Peter, Wagner, Erwin F.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171977/
https://ncbi.nlm.nih.gov/pubmed/14769860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200308155
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