Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase

Degradation of specific protein substrates by the anaphase-promoting complex/cyclosome (APC) is critical for mitotic exit. We have identified the protein Xenopus nuclear factor 7 (Xnf7) as a novel APC inhibitor able to regulate the timing of exit from mitosis. Immunodepletion of Xnf7 from Xenopus la...

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Autores principales: Casaletto, Jessica B., Nutt, Leta K., Wu, Qiju, Moore, Jonathan D., Etkin, Laurence D., Jackson, Peter K., Hunt, Tim, Kornbluth, Sally
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2005
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171901/
https://ncbi.nlm.nih.gov/pubmed/15824132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200411056
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