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Phosphorylation of p66Shc and forkhead proteins mediates Aβ toxicity
Excessive accumulation of amyloid β-peptide (Aβ) plays an early and critical role in synapse and neuronal loss in Alzheimer's Disease (AD). Increased oxidative stress is one of the mechanisms whereby Aβ induces neuronal death. Given the lessened susceptibility to oxidative stress exhibited by m...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171879/ https://ncbi.nlm.nih.gov/pubmed/15837797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200410041 |
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